太赫兹时域光谱分析测试

分析测试

太赫兹时域光谱(Terahertz Time-domain Spectroscopy)用于表征物质在太赫兹(Terahertz, 0.1-10 THz)波段的光谱响应函数，从而获得物质的微观结构信息。太赫兹时域光谱的应用方法是：当太赫兹电场穿透样品时，样品与太赫兹相互作用，在某些特征频率发生共振吸收，通过标定这些特征频率，达到区分样品种类、分析物质微观结构等目的。太赫兹时域光谱常用于药品、化学试剂等物质种类鉴别。在测量中，样品一般是粉末、固体等形态。

图中为太赫兹时域光谱在物质鉴别中的应用，红色和蓝色曲线为4-羟基苯甲酸样品的吸收系数和折射率，从图中得到4-羟基苯甲酸样品在1.877、3.601、5.128、5.595 THz频率下有明显的特征吸收峰。可以用于物质种类鉴别，结合量子化学计算推测物质微观结构。

图一 4-羟基苯甲酸吸收系数与折射率示意图

应用

论文：

[7] 骆国防,齐济,刘雅丽,何明霞,黄华,曲秋红*,张逸竹*,吡啶二甲酸结构异构体的太赫兹光谱分析,光谱学与光谱分析 45 (4), 908-913 (2025)

[6] Pengfei Wang, Ying Li, Weifang Han, Yuyue Yan, Chunyi Zhang, Qiuhong Qu, Xu Zhang, Liyuan Liu, Xiaohong Sun, Xiaonan Yang*, Mingxia He, The supramolecular synthon behavior within cocrystals of pyrazinamide and alkyl dicarboxylic acids: A perspective from terahertz spectroscopy and quantum chemical calculation, Talanta 278, 126489 (2024).

[5] Pengfei Wang*, Yuman Zhang, Juntong Zhao, Yuyue Yan, Liyuan Liu, Hongwei Zhao, Mingxia He, The collective vibrational modes of dihydropyridine in nifedipine studied by terahertz spectroscopy, Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy 292, 122404 (2023).

[4] Pengfei Wang, Juntong Zhao, Yuman Zhang, Zhongjie Zhu, Liyuan Liu, Hongwei Zhao, Xianchao Yang, Xiaonan Yang, Xiaohong Sun*, Mingxia He, The fingerprints of nifedipine/isonicotinamide cocrystal polymorph studied by terahertz time-domain spectroscopy, International Journal of Pharmaceutics 620, 121759 (2022).

[3] Pengfei Wang, Xiangchao Wang, Liyuan Liu, Hongwei Zhao, Wei Qi, Mingxia He*, The Hydration Shell of Monomeric and Dimeric Insulin Studied by Terahertz Time-Domain Spectroscopy, Biophysical Journal 117(3), 533-541 (2019).

[2] Pengfei Wang, Liyuan Liu, Xiangchao Wang, Jianbing Zhang, Wei Qi, Hongwei Zhao, Zhen Tian, Mingxia He*, Label-free measurements on the solution of monomeric and dimeric insulin using a periodical terahertz split ring resonator, Chemical Physics 525, 110390 (2019).

[1] Pengfei Wang, Yuefei Wang, Liyuan Liu, Jinwu Zhao, Zhen Tian, Wei Qi, Jianbing Zhang, Hongwei Zhao, Mingxia He*, Self-assembled chiral nanoribbons studied by terahertz time-domain spectroscopy and other biological methods, Chemical Physics Letters 717, 130-135 (2019).

专利：

[1]何明霞;陈雨昂;曲秋红;张逸竹;齐济。一种基于太赫兹时域光谱的绝缘油中糠醛的检测方法。发明专利。申请日：2024年12月23日。授权公告日：2025年03月28日。专利号：ZL202411897511.8。